Inspirational quotes with pathogens.
The talk of sin is of course to many a big turn-off; to others, an even bigger myth - because in reality, sin is like the spiritual equivalent of a microscopic parasite, or a virus, or better yet even, an infectious disease. And just as one might never know of, until visiting a competent doctor, the tiny pathogens progressively eroding one's body, so we might never know that in sin we are eroding our being and losing direction until hearing the Word of God rightfully applied. Therefore I ask, which of the doctors would then be the more competent: the one who finds the problem and gives the solution, or the one who willfully ignores the problem (or rather finds the problem when it is much too late)? Seldom does anyone write off the knowledge of medicine for the physical body as primitive practice, so neither must the knowledge of the Word of God for one's spiritual well-being remain written off as primitive practice - quite the opposite really. As it is written thus: 'Lean not on your own understanding.
Somatic hypermutation gives rise to B cells bearing mutant immunoglobulin molecules on their surface. Some of these mutant immunoglobulins have substitutions in the antigen-binding site that increase its affinity for the antigen. B cells bearing these mutant high-affinity immunoglobulin receptors compete most effectively for binding to antigen and are preferentially selected to mature into antibody-secreting plasma cells. The mutant antibodies that emerge from the selection do not have a random distribution of amino-acid substitutions. The changes are concentrated at positions in the heavy-chain and light-chain CDR loops that form the antigen-binding site and directly contact antigen. As the adaptive immune response to infection proceeds, antibodies of progressively higher affinity for the infecting pathogen are produced – a phenomenon called affinity maturation. Affinity maturation is a process of evolution in which variant immunoglobulins generated in a random manner are subjected to selection for improved binding to a pathogen. It achieves in a few days what would require thousands, if not millions, of years of classical Darwinian evolution in a conventional gene. This capacity for extraordinarily rapid evolution in pathogen-binding immunoglobulins is a major factor in allowing the human immune system to keep up with the generally faster-evolving pathogens.
This medical view of an ideal male who was insulated from pathogens was inextricably bound up with a parallel discourse about the maintenance of strong ego boundaries, a psychic investment in one’s bodily peripheries that effected a gradual closing (and, one might say, a closing off) of the male body, at once from the outer world of dangerous stimuli and from the inner world of threatening passions. Without a doubt, as Norbert Elias has shown, in the western world both men and women experienced a shift in their sense of personal boundaries during the early modern era where, amid changing social circumstances, rising thresholds of repugnance and shame were manifested among the upper-classes as a growing aversion to their own bodily functions and to the bodies of others. The changes wrought by new developments in table manners and etiquette were extended by the introduction of hygienic practices in the eighteenth and nineteenth centuries that endeavored to maximise the order and cleanliness of the social body while futher compartmentalising the bourgeois self as a discrete bodily unit.
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