Quotes with disproportionate

Inspirational quotes with disproportionate.

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We can't leave the past in the past because, the past is who we are. It's like saying I wish I could forget English. So, there is no leaving the past in the past. It doesn't mean the past has to define and dominate everything in the future. The fact that I had a temper in my teens doesn't mean I have to be an angry person for the rest of my life. It just means that I had allot to be angry about but, didn't have the language and the understanding to know what it was and how big it was. I thought my anger was disproportionate to the environment which is what is called having a bad temper but, it just means that I underestimated the environment and my anger was telling me how wide and deep child abuse is in society but, I didn't understand that consciously so I thought my anger was disproportionate to the environment but, it wasn't. There is almost no amount of anger that's proportionate to the degree of child abuse in the world. The fantasy that you can not be somebody that lived through what you lived through is damaging to yourself and to your capacity to relate to others. People who care about you, people who are going to grow to love you need to know who you are and that you were shaped by what you've experienced for better and for worse. There is a great deal of challenge in talking about these issues. Lots of people in this world have been hurt as children. Most people have been hurt in this world as children and when you talk honestly and openly it's very difficult for people. This is why it continues and continues.If you can get to the truth of what happened if you can understand why people made the decisions they've made even if you dont agree with the reason for those decisions knowing the reasons for those decisions is enormously important in my opinion. The more we know the truth of history the more confidently we can face the future without self blame.

The researchers looked deeper into these observations, in hopes of gaining insight into the mechanisms underlying the high evolutionary rate and extraordinary immunologic plasticity of influenza HA. They probed in more detail the precise codons that are used by the virus to encode the influenza HA1 protein. The discriminated between codons on the basis of volatility. Each three-nucleotide codon is related by a single nucleotide change to nine 'mutational neighbours.' Of those nine mutations, some proportion change the codon to a synonymous codon and some change it to a nonsynonymous one, which directs the incorporation of a different amino acid into the protein. More volatile codons are those for which a larger proportion of those nine mutational neighbours encode an amino acid change. The use of particular codons in a gene at a frequency that is disproportionate to their random selection for encoding a chosen amino acid is termed codon bias. Such bias is common and is influenced by many factors, but here the collaborators found strong evidence for codon bias that was particular for and restricted to the amino acids making up the HA1 epitopes. Remarkably, they observed that influenza employs a disproportionate number of volatile codons in its epitope-coding sequences. There was a bias for the use of codons that had the fewest synonymous mutational neighbours. In other words, influenza HA1 appears to have optimized the speed with which it can change amino acids in its epitopes. Amino acid changes can arise from fewer mutational events. The antibody combining regions are optimized to use codons that have a greater likelihood to undergo nonsynonymous single nucleotide substitutions : they are optimized for rapid evolution.



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